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450 West Drive
Chapel Hill, NC

University of North Carolina, Chapel Hill

The Emanuele Lab studies cell cycle regulation using systematic technologies and traditional cell, molecular and biochemical techniques.


Great job Anthony for being awarded "Best Poster" at the 2017 UNC Lineberger Cancer Center scientific retreat. 

Congrats to Allie Mills for her paper in The Journal of Biological Chemistry

In this exciting study, featured as the journals cover article, Allie established a novel connection between NUSAP1, a microtubule binding protein and substrate of the ubiquitin system, and a mitotic SUMO ligase. Read her article here



Congrats Raj on winning the UNC cancer center Pagano Award in recognition of your paper describing a circuit involved in proliferation control!

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Great job Raj on another paper in Cell Reports

A long standing question is how the oncogenic kinase AKT promotes cell cycle progression. This study shows that Cyclin F, a non-canonical Cyclin, and substrate receptor for the SCF family of ubiquitin ligases, is a bona fide AKT substrate. This connects oncogenic AKT signaling, which is recurrently activated in many cancers, to control of the core cell cycle oscillator. This study was a collaboration with out colleauges at UNC in the Liu lab. Read about it here

Congrats to Raj Choudhury on accepting a position at Glaxo-Smith Kline in the Philadelphia area. You'll be missed!


Nice work Xianxi on her paper in Molecular and Cellular Biology

This paper describes a paradoxical relationship between the cell cycle transcription factor FoxM1 and a Cul4-based ubiquitin ligase. FoxM1 is recurrently activated in aggressive breast and ovarian cancers, and this study shows that VprBP, a substrate receptor for Cul4, controls both the degradation and activation of FoxM1. Moreover, we showed that VprBP is overexpressed in high-grade serous ovarian tumors, potentially contributing to FoxM1 activation in malignancy. This study was a collaborative efforts with our colleauges at UNC, in the Bowers and Bae-Jump labs. Read more here

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Big congratulations to Raj and the rest of the lab on our first paper, describing a novel circuit in cell cycle regulation. 

This paper describes a feedback circuit that controls cell cycle entry. It centers on two crucial cell cycle ubiquitin ligases, the SCF and APC/C and shows that they coordinately control each other during progression through the cell cycle. Read more here