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450 West Drive
Chapel Hill, NC

University of North Carolina, Chapel Hill

The Emanuele Lab studies cell cycle regulation using systematic technologies and traditional cell, molecular and biochemical techniques.

News & Pics

Great job Raj on your new paper out in Cell Reports!

Michael Emanuele

A long standing question is how the oncogenic kinase AKT promotes cell cycle progression. This study shows that Cyclin F, a non-canonical Cyclin, and substrate receptor for the SCF family of ubiquitin ligases, is a bona fide AKT substrate. This connects oncogenic AKT signaling, which is recurrently activated in many cancers, to control of the core cell cycle oscillator. This study was a collaboration with out colleagues at UNC in the Liu lab. Read about it here

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